Where should signature sheets be maintained?

• A. Investigator/Institution and Sponsor
• B. Public Library
• C. Participants' homes
• D. Regulatory Authority records

Answer: (A)

Signature sheets are part of essential trial documents that prove who gave consent and who performed each trial activity. They must be kept where the trial is conducted and also by the sponsor, so both the investigator’s site and the sponsor have access for monitoring, auditing, and regulatory inspections. This arrangement protects confidentiality and ensures a clear chain of responsibility. Storing these records at a public library or in participants’ homes would compromise privacy and accessibility, and while regulatory authorities may review them during inspections, they are not the primary place of retention. Keeping them with the investigator/institution and the sponsor provides proper governance and long‑term archiving.