Which term describes an investigator assigned the responsibility for the coordination of investigators at different centers participating in a multicenter trial?

• A. Coordinating Committee
• B. Case Report Form (CRF)
• C. CRO
• D. Coordinating Investigator

Answer: (D)

The term describes the person designated to coordinate investigators at different centers participating in a multicenter trial. This role is focused on unifying activities across sites, ensuring consistent protocol implementation, training, and communications with the sponsor, as well as facilitating timely data collection and safety reporting across all centers. The coordinating investigator acts as the central point for coordinating site-level efforts, resolving cross-site issues, and maintaining trial integrity across multiple locations.

This differentiates from a Coordinating Committee, which is a governance group that guides the trial rather than directly managing cross-site operations; a Case Report Form is the data collection tool used for recording trial data; and a CRO, or Contract Research Organization, is an external organization that handles trial activities rather than representing a lead investigator coordinating across sites.