Which term refers to a study conducted across more than one site to improve generalizability?

• A. Multicenter Trials
• B. Design Configuration
• C. Trials to Show Superiority
• D. Type of Comparison

Answer: (A)

The concept here is testing across multiple locations to ensure findings apply broadly. When a study is conducted at more than one site, it’s called a multicenter trial. This approach increases generalizability by including diverse patient populations, different investigators, and varying practice settings, so the results are more likely to reflect real-world use rather than being limited to a single center’s characteristics. In GCP terms, multicenter trials require careful coordination: standardized protocols, consistent training, centralized data management, and uniform monitoring to keep data and conduct comparable across sites.

That’s why multicenter trials best fit the description of improving generalizability. The other terms don’t describe a study’s scope across sites: design configuration isn’t a standard descriptor for multi-site scope; trials to show superiority focuses on the hypothesis about treatment effect, not the number of sites; and type of comparison refers to how treatments are compared, not where the study is conducted.